SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
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Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical propertiesInhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARASkeletal muscle wasting and renewal: a pivotal role of myokine IL-6Other targeted drugs in melanomaTargeting TGF-β signaling in cancerTargeting the Transforming Growth Factor-β Signaling in Cancer TherapyIntegration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetryActivin receptor-like kinases: a diverse family playing an important role in cancerForward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinasesSignaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell developmentAmino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activitiesTransforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function.The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cellsIntegral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening.Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis.Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafishRole of TGF-beta1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent mannerTGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB.Dynamic regulation of CD24 and the invasive, CD44posCD24neg phenotype in breast cancer cell linesThe fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitorTGFβ signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis.Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke.Heterotaxin: a TGF-β signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos.BMP12 induces tenogenic differentiation of adipose-derived stromal cells.Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathologyAn essential role for transcription before the MBT in Xenopus laevis.Identification of ALK5 inhibitor via structure-based virtual screening and ADMET prediction.The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitorsSmad3 as a mediator of the fibrotic response.Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiationA Small Dibromotyrosine Derivative Purified From Pseudoceratina Sp. Suppresses TGF-β Responsiveness by Inhibiting TGF-β Type I Receptor Serine/Threonine Kinase Activity.Endothelial cell transforming growth factor-β receptor activation causes tacrolimus-induced renal arteriolar hyalinosis.Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafishMolecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.
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P2860
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@en
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@nl
type
label
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@en
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@nl
prefLabel
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@en
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@nl
P2093
P356
P1476
SB-505124 is a selective inhib ...... eceptors ALK4, ALK5, and ALK7.
@en
P2093
Christopher Major
Nicholas J Laping
Stacey DaCosta Byfield
P304
P356
10.1124/MOL.65.3.744
P577
2004-03-01T00:00:00Z