about
LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast modelMicroglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosisDIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa.A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-moleculeMitochondria-dependent apoptosis in yeast.The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms.New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.p53 family interactions and yeast: together in anticancer therapy.Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Hydrogen peroxide-induced secondary necrosis in conidia of Aspergillus fumigatus.Chronological aging in conidia of pathogenic Aspergillus: Comparison between species.Contribution of yeast and plant research for improving human health.Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.Inhibition of protein kinase C by synthetic xanthone derivatives.Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay.Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms.Using yeast to uncover the regulation of protein kinase Cδ by ceramide.Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.A yeast model of the Parkinson's disease-associated protein Parkin.Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.Production and purification of theVP1 capsid protein of a novel canine norovirus using the Saccharomyces cerevisiae expression systemDesign and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffoldPotential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assaysAspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathwayNew Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity EvaluationInterference of aging media on the assessment of yeast chronological life span by propidium iodide stainingEndocytosis inhibition during H2O2-induced apoptosis in yeastDistinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanismsDifferential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell systemCytotoxic Activity of Royleanone Diterpenes from Benth
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Lucília Saraiva
@ast
Lucília Saraiva
@en
Lucília Saraiva
@es
Lucília Saraiva
@nl
Lucília Saraiva
@sl
type
label
Lucília Saraiva
@ast
Lucília Saraiva
@en
Lucília Saraiva
@es
Lucília Saraiva
@nl
Lucília Saraiva
@sl
prefLabel
Lucília Saraiva
@ast
Lucília Saraiva
@en
Lucília Saraiva
@es
Lucília Saraiva
@nl
Lucília Saraiva
@sl
P106
P1153
35585255500
P21
P31
P496
0000-0002-9531-4939