Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.

P2860

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Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

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2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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name

Risk assessment of drug-drug i ...... ng the drug discovery process.

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Risk assessment of drug-drug i ...... ng the drug discovery process.

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Risk assessment of drug-drug i ...... ng the drug discovery process.

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Risk assessment of drug-drug i ...... ng the drug discovery process.

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Risk assessment of drug-drug i ...... ng the drug discovery process.

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Risk assessment of drug-drug i ...... ng the drug discovery process.

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P1476

Risk assessment of drug-drug i ...... ng the drug discovery process.

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P2093

Hideki Hirabayashi

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Teruaki Okuda

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Tomoko Igari

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Toshiya Moriwaki

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Yasushi Fujioka

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Yohei Kosugi

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P2860

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Examination of 209 drugs for inhibition of cytochrome P450 2C8

Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions.

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data.

Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant.

P304

336-344

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scholarly article

P356

10.3109/00498254.2013.837988

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English

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P478

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2013-09-27T00:00:00Z

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24074236

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Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

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P2860

P2860

Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

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P1433

P1476

P2093

P2860

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P356

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P433

P478

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P698

P356

P1433

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P31

P356

P407

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P698