Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
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The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneityInactivation of p53 rescues the maintenance of high risk HPV DNA genomes deficient in expression of E6TIN2, a new regulator of telomere length in human cellsKeratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADDNek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsImmortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathwayRole of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationThe keratin-binding protein Albatross regulates polarization of epithelial cellsControl of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseEvidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cellsSmurf2 up-regulation activates telomere-dependent senescenceIdentification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complexGrowth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASGNFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cellsEpstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5hDREF regulates cell proliferation and expression of ribosomal protein genesDown-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesisComplex roles for telomeres and telomerase in breast carcinogenesisNormal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteinsCellular Senescence:Ex Vivop53-Dependent Asymmetric Cell KineticsImmortalization of Primary Keratinocytes and Its Application to Skin ResearchEpigenetic changes during cell transformationHuman papillomavirus induced transformation in cervical and head and neck cancersSenescence in adipose-derived stem cells and its implications in nerve regenerationA Combined In Vitro Imaging and Multi-Scale Modeling System for Studying the Role of Cell Matrix Interactions in Cutaneous Wound HealingImplications of telomeres and telomerase in endometrial pathologyRedox control of senescence and age-related diseasePolycomb CBX7 has a unifying role in cellular lifespanPML interaction with p53 and its role in apoptosis and replicative senescenceCockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodelingThe epigenomics of cancerIncreased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epitheliumFunctional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survivalInk4a/Arf expression is a biomarker of agingTelomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survivalHuman keratinocytes are efficiently immortalized by a Rho kinase inhibitorAn abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome
P2860
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P2860
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@en
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@nl
type
label
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@en
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@nl
prefLabel
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@en
Both Rb/p16INK4a inactivation ...... talize human epithelial cells.
@nl
P2093
P356
P1433
P1476
Both Rb/p16INK4a inactivation ...... rtalize human epithelial cells
@en
P2093
P2888
P356
10.1038/23962
P407
P577
1998-11-01T00:00:00Z
P6179
1039433443