Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.
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PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndromeTwo faces of p53: aging and tumor suppressionC/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injuryp53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Radiation enteropathy--pathogenesis, treatment and preventionA novel radioprotective function for the mitochondrial tumor suppressor protein Fus1A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced deathThe Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human PrimatesG1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target PtprvReversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacyDissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activityDrosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantationArgininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryosDeletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.A new class of molecular targeted radioprotectors: GSK-3beta inhibitorsPathologies associated with the p53 response.Recombinant human MFG-E8 attenuates intestinal injury and mortality in severe whole body irradiation in ratsKrüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.Laser capture microdissected mucosa versus whole tissue specimens for assessment of radiation-induced dynamic molecular and pathway changes in the small intestineAmifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulationAn agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleenThe multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.Inflammation and p53: A Tale of Two StressesPharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiationp53 protects against LPS-induced lung endothelial barrier dysfunction.Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymesWip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agentsA small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in miceActivation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-κB/p53 Signaling in Lethally Irradiated Mice.p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.Accelerated hematopoietic toxicity by high energy (56)Fe radiation.Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo.
P2860
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P2860
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@en
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@nl
type
label
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@en
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@nl
prefLabel
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@en
Dual effect of p53 on radiatio ...... o-intestinal syndrome in mice.
@nl
P2093
P2860
P356
P1433
P1476
Dual effect of p53 on radiatio ...... ro-intestinal syndrome in mice
@en
P2093
Andrei V Gudkov
Elena A Komarova
John R Goldblum
Kaihua Wang
Konstantin Christov
Tatiana V Golovkina
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207494
P407
P577
2004-04-01T00:00:00Z