Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
about
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and AbetaGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsPS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsUncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Interleukin-3 prevents neuronal death induced by amyloid peptideLow density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's diseaseDecreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic micePresenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cellsCDK5 activator protein p25 preferentially binds and activates GSK3βImmunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse modelGenetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.Presenilins regulate the cellular level of the tumor suppressor PTEN.Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologicallyCellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster.Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signalingNeurogenesis and Alzheimer's disease: at the crossroads.Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin.Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3Neuronal survival induced by neurotrophins requires calmodulin.
P2860
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P2860
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@en
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@nl
type
label
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@en
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@nl
prefLabel
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@en
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
@nl
P2093
P1476
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
@en
P2093
P304
P356
10.1523/JNEUROSCI.19-13-05360.1999
P407
P577
1999-07-01T00:00:00Z