The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Sumoylation of eIF4E activates mRNA translation4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferationFibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathwaysRibavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?The mTOR signalling pathway in human cancerFoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and RictorEvaluation of eIF4E expression in an osteosarcoma-specific tissue microarrayBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisNMR structures of double loops of an RNA aptamer against mammalian initiation factor 4AUpdated overview of current biomarkers in head and neck carcinomaSignalling to eIF4E in cancermTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsTargeting translation initiation in breast cancerAltering chemosensitivity by modulating translation elongationmTOR and cancer therapyNontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translationTargeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotideResistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformationeIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcriptionAutism-related deficits via dysregulated eIF4E-dependent translational control.Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cellsTumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferationNutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element.Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissuesProtein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.Molecular markers of paragangliomas/pheochromocytomasA novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisRegulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cellsInhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.Extracellular signal-regulated kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell lymphoma.Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancerTargeting the translational machinery as a novel treatment strategy for hematologic malignanciesThe eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translationNew frontiers in translational control of the cancer genomeWith TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aginghnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation.Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
P2860
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P2860
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@en
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@nl
type
label
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@en
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@nl
prefLabel
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@en
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@nl
P2093
P2860
P356
P1433
P1476
The translation factor eIF-4E ...... with c-Myc in lymphomagenesis.
@en
P2093
Davide Ruggero
Lorenzo Montanaro
Paola Londei
P2860
P2888
P304
P356
10.1038/NM1042
P407
P577
2004-04-18T00:00:00Z