Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism.
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Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafishElevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosisAlzheimer's Disease: Mechanism and Approach to Cell TherapyThree Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular MetabolismFunctional O-GlcNAc modifications: implications in molecular regulation and pathophysiologyChemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell DeathGlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylationSubstrate and product analogues as human O-GlcNAc transferase inhibitorsImpact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heartAging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway ratsO-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation.Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragmentMapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.The emerging link between O-GlcNAc and Alzheimer disease.Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy.A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasomeGlucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell.Chemical approaches to understanding O-GlcNAc glycosylation in the brain.Hsp90 regulates O-linked β-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked β-N-acetylglucosamine modification in endothelial cells.O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signalingDoes O-GlcNAc play a role in neurodegenerative diseases?O-GlcNAc cycling modulates neurodegeneration.Metabolic control of proteasome function.Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.O-GlcNAc cycling: implications for neurodegenerative disorders.O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapsesThe role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses.O-linked beta-N-acetylglucosaminylation in mouse embryonic neural precursor cells.Modulation of transcription factor function by O-GlcNAc modification.Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.Regulation of autophagy by protein post-translational modification.Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus.Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disabilityChemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation.O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors.
P2860
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P2860
Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@en
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@nl
type
label
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@en
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@nl
prefLabel
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@en
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@nl
P2093
P1476
Accumulation of protein O-GlcN ...... with high O-GlcNAc metabolism.
@en
P2093
Andrew J Paterson
Fengxue Zhang
J Michael Wyss
Jeffrey E Kudlow
Joanne McAndrew
Ken-Ichiro Fukuchi
P304
P356
10.1111/J.1471-4159.2004.02389.X
P407
P577
2004-05-01T00:00:00Z