Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. - Wikidata - awgldk - TriplyDB

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

http://www.wikidata.org/entity/Q44898088

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Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state Endothelial Plasticity: Shifting Phenotypes through Force Feedback Acute Myocardial Response to Stretch: What We (don't) Know The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation In vivo modulation of endothelial polarization by Apelin receptor signalling Renal autoregulation in health and disease A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy RAGE mediates accelerated diabetic vein graft atherosclerosis induced by combined mechanical stress and AGEs via synergistic ERK activation Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα Endothelin-induced, long lasting, and Ca2+ influx-independent blockade of intrinsic secretion in pituitary cells by Gz subunits Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice Mechanical dynamics in live cells and fluorescence-based force/tension sensors Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles.Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II.Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.Increased afterload induces pathological cardiac hypertrophy: a new in vitro model A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries.G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons.Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways.Renin Angiotensin system as a regulator of cell volume. Implications to myocardial ischemia Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes.Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice Drug-based therapies for vascular disease in Marfan syndrome: from mouse models to human patients.Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome.Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice Endothelin signalling regulates volume-sensitive Cl- current via NADPH oxidase and mitochondrial reactive oxygen species A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure.The science of stroke: mechanisms in search of treatments.

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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

http://www.wikidata.org/entity/Q44898088

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2004 nî lūn-bûn

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Akiyoshi Fukamizu

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10.1038/NCB1137

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