Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype.
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Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrowInduction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis.CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis.Commercial bovine proteoglycan is highly arthritogenic and can be used as an alternative antigen source for PGIA model.PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity.Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic miceTolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress.Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparinTh1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis.B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide.Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid ArthritisSuppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritisIn vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritisNon-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.Development of proteoglycan-induced arthritis is independent of IL-17.Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 miceBALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis.Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.Of mice and men: how animal models advance our understanding of T-cell function in RA.An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritisThe influence of MHC class II molecules containing the rheumatoid arthritis shared epitope on the immune response to aggrecan G1 and its peptides.B cell-specific expression of inducible costimulator ligand is necessary for the induction of arthritis in mice.In Vivo Models for Inflammatory Arthritis.
P2860
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P2860
Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@en
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@nl
type
label
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@en
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@nl
prefLabel
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@en
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@nl
P2093
P2860
P356
P1476
Achievement of a synergistic a ...... onse toward the Th1 phenotype.
@en
P2093
Anita Hanyecz
Chris P M Broeren
Suzanne E Berlo
Sándor Szántó
Tibor T Glant
P2860
P304
P356
10.1002/ART.20180
P577
2004-05-01T00:00:00Z