Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus.
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Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agentsCannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsyCannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.Endocannabinoids in the dentate gyrus.Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system.Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current.Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neuronsEpileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activityDevelopment of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.Excitatory afferents to CA3 pyramidal cells display differential sensitivity to CB1 dependent inhibition of synaptic transmission.Endocannabinoids block status epilepticus in cultured hippocampal neurons.Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy.In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons.The analgesic potential of cannabinoids.Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate.Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3.Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus.The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channelsThe Role of BK Channels in Antiseizure Action of the CB1 Receptor Agonist ACEA in Maximal Electroshock and Pentylenetetrazole Models of Seizure in MiceEndocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress in Vitro.Cannabinoid receptor 1/2 double-knockout mice develop epilepsy.Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy.Cannabinoid-mediated short-term plasticity in hippocampus.Leptin: role over central nervous system in epilepsySaikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy
P2860
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P2860
Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@en
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@nl
type
label
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@en
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@nl
prefLabel
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@en
Activation of the cannabinoid ...... ilepsy and status epilepticus.
@nl
P2093
P921
P356
P1476
Activation of the cannabinoid ...... pilepsy and status epilepticus
@en
P2093
Billy R Martin
Katherine W Falenski
Robert E Blair
Robert J DeLorenzo
Sompong Sombati
P304
P356
10.1124/JPET.105.100354
P407
P577
2006-02-09T00:00:00Z