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(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementMms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase IIProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessmentEvidence that humans metabolize benzene via two pathwaysInhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 CellsEnvironmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.Topoisomerase II inhibition involves characteristic chromosomal expression patterns.Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαMutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Cleavage of plasmid DNA by eukaryotic topoisomerase II.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismEtoposide quinone is a redox-dependent topoisomerase II poisonEffects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases.Oxidative metabolites of curcumin poison human type II topoisomerases.The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.DNA topoisomerase II, genotoxicity, and cancerEpimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingImpact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.A mechanism for 1,4-Benzoquinone-induced genotoxicity.Topoisomerase II and leukemia.Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents.Hydroquinone, a benzene metabolite, and leukemia: a case report and review of the literature.Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects.Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.Redox state alters anti-cancer effects of wedelolactone.Etoposide quinone is a covalent poison of human topoisomerase IIβ.Cadmium is a catalytic inhibitor of DNA topoisomerase II.Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation.Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
1,4-Benzoquinone is a topoisomerase II poison.
@en
1,4-Benzoquinone is a topoisomerase II poison.
@nl
type
label
1,4-Benzoquinone is a topoisomerase II poison.
@en
1,4-Benzoquinone is a topoisomerase II poison.
@nl
prefLabel
1,4-Benzoquinone is a topoisomerase II poison.
@en
1,4-Benzoquinone is a topoisomerase II poison.
@nl
P2093
P356
P1433
P1476
1,4-Benzoquinone is a topoisomerase II poison.
@en
P2093
Carolyn A Felix
Kenneth D Bromberg
Neil Osheroff
R Hunter Lindsey
P304
P356
10.1021/BI049756R
P407
P577
2004-06-01T00:00:00Z