Structure of bleomycin-induced DNA double-strand breaks: predominance of blunt ends and single-base 5' extensions.
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Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae.Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesionProcessing of damaged DNA ends for double-strand break repair in mammalian cellsArabidopsis COPPER MODIFIED RESISTANCE1/PATRONUS1 is essential for growth adaptation to stress and required for mitotic onset control.Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Reactivity of Nucleic Acid Radicals.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationGene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.In vitro repair of complex unligatable oxidatively induced DNA double-strand breaks by human cell extracts.Determination of hypersensitivity to genotoxic agents among Escherichia coli single gene knockout mutantsA short DNA sequence confers strong bleomycin binding to hairpin DNAsModified bleomycin disaccharides exhibiting improved tumor cell targetingThe natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system.Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage.Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycinDouble-strand breaks from a radical commonly produced by DNA-damaging agents.Structural features facilitating tumor cell targeting and internalization by bleomycin and its disaccharide.The determination of the DNA sequence specificity of bleomycin-induced abasic sites.Cellular senescence and cancer chemotherapy resistance.Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens.Bleomycins: towards better therapeutics.The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathwayCoordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase.Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavageTreatment of cancer with cryochemotherapy.DNA double strand cleavage via interstrand hydrogen atom abstraction.The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks.Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation.The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence.The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells.A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans.Induction of CAF-1 expression in response to DNA strand breaks in quiescent human cells.Characterization of bleomycin-mediated cleavage of a hairpin DNA library.DNA methylation reduces binding and cleavage by bleomycin.Activation of PARP-1 in response to bleomycin depends on the Ku antigen and protein phosphatase 5.Lysine-enediyne conjugates as photochemically triggered DNA double-strand cleavage agents.DNApol-ϵ gene is indispensable for the survival and growth of Drosophila melanogaster.Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles.
P2860
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P2860
Structure of bleomycin-induced DNA double-strand breaks: predominance of blunt ends and single-base 5' extensions.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Structure of bleomycin-induced ...... and single-base 5' extensions.
@en
Structure of bleomycin-induced ...... and single-base 5' extensions.
@nl
type
label
Structure of bleomycin-induced ...... and single-base 5' extensions.
@en
Structure of bleomycin-induced ...... and single-base 5' extensions.
@nl
prefLabel
Structure of bleomycin-induced ...... and single-base 5' extensions.
@en
Structure of bleomycin-induced ...... and single-base 5' extensions.
@nl
P2093
P356
P1433
P1476
Structure of bleomycin-induced ...... and single-base 5' extensions.
@en
P2093
P304
P356
10.1021/BI00440A016
P407
P577
1989-07-01T00:00:00Z