Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling.
about
Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force.Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in miceThe adaptor protein Disabled-2: new insights into platelet biology and integrin signalingMatrix-specific suppression of integrin activation in shear stress signaling.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceSulfatides partition disabled-2 in response to platelet activation.20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells.Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome.Methods for genetic modification of megakaryocytes and platelets.Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.Disabled-2: A modular scaffold protein with multifaceted functions in signaling.Distinct effects of Disabled-2 on transferrin uptake in different cell types and culture conditions.Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasisC-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm developmentDisabled-2 modulates homotypic and heterotypic platelet interactions by binding to sulfatides.Autocrine signaling of platelet-derived growth factor regulates disabled-2 expression during megakaryocytic differentiation of K562 cells.Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection.Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets.
P2860
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P2860
Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling.
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Disabled-2 is a negative regulator of integrin alpha
@nl
Disabled-2 is a negative regul ...... n adhesion and cell signaling.
@en
type
label
Disabled-2 is a negative regulator of integrin alpha
@nl
Disabled-2 is a negative regul ...... n adhesion and cell signaling.
@en
prefLabel
Disabled-2 is a negative regulator of integrin alpha
@nl
Disabled-2 is a negative regul ...... n adhesion and cell signaling.
@en
P2093
P50
P356
P1476
Disabled-2 is a negative regul ...... en adhesion and cell signaling
@en
P2093
Arnold Stern
Chi-Huei Wang
Hsueh-Ling Hsu
Jer-Tsong Hsieh
Ju-Chien Cheng
P304
42279-42289
P356
10.1074/JBC.M402540200
P407
P577
2004-07-26T00:00:00Z