Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
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High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix compositionEpithelial to Mesenchymal Transition in a Clinical PerspectiveTargeting the Transforming Growth Factor-β Signaling in Cancer TherapySIBLINGs and SPARC families: their emerging roles in pancreatic cancerBMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formationDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyEpithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases.Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.Targeting the transforming growth factor-beta signaling pathway in human cancer.Two faces of TGF-beta1 in breast cancer.Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma.Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes.LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft.miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway.Chemotherapeutic Targeting of the Transforming Growth Factor-β Pathway in Breast Cancers.Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208).Role of transforming growth factor-beta in cancer progression.Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 proteinTargeting signal transduction in pancreatic cancer treatment.Selective killing of Smad4-negative tumor cells via a designed repressor strategyThe Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer MetastasisSmad4 is required to regulate the fate of cranial neural crest cells.Transforming growth factor-beta: a target for cancer therapy.Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer.TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases.Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGFβ1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p.ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma.EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.Berbamine enhances the antineoplastic activity of gemcitabine in pancreatic cancer cells by activating transforming growth factor-β/Smad signaling.Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance.EW-7203, a novel small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor/activin receptor-like kinase-5, blocks TGF-β1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells.Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function.Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer.Imbalanced expression of Tif1γ inhibits pancreatic ductal epithelial cell growth.TGF-β in pancreatic cancer initiation and progression: two sides of the same coinThe Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance.
P2860
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P2860
Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Targeting endogenous transform ...... its their invasive phenotype1.
@en
Targeting endogenous transform ...... its their invasive phenotype1.
@nl
type
label
Targeting endogenous transform ...... its their invasive phenotype1.
@en
Targeting endogenous transform ...... its their invasive phenotype1.
@nl
prefLabel
Targeting endogenous transform ...... its their invasive phenotype1.
@en
Targeting endogenous transform ...... its their invasive phenotype1.
@nl
P2093
P1433
P1476
Targeting endogenous transform ...... bits their invasive phenotype1
@en
P2093
Gayathri Subramanian
Glenn McEnroe
Linda Higgins
Roderich E Schwarz
Sarvajit Chakravarty
Sundeep Dugar
P304
P356
10.1158/0008-5472.CAN-04-0018
P407
P577
2004-08-01T00:00:00Z