Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

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http://www.wikidata.org/entity/Q45013818
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone lossSmall molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens.Statins and cardiovascular diseases: from cholesterol lowering to pleiotropyLovastatin Inhibits Low Molecular Weight Hyaluronan Induced Chemokine Expression via LFA-1 and Decreases Bleomycin-Induced Pulmonary Fibrosis.Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes.Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 bindingThe C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsProtein-protein interactions as drug targets.Pleiotropic effects of statins. - Basic research and clinical perspectives -.Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells.NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domainA novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood.Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity.A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.10th anniversary Inflammation and Immune Diseases Drug Discovery and Development Summit. 20-21 March 2006, New Brunswick, USA.
P2860

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

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http://www.wikidata.org/entity/Q45013818
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Improved lymphocyte function-a ...... changes in vitro and ex vivo.
@en
Improved lymphocyte function-associated antigen-1
@nl
type
label
Improved lymphocyte function-a ...... changes in vitro and ex vivo.
@en
Improved lymphocyte function-associated antigen-1
@nl
prefLabel
Improved lymphocyte function-a ...... changes in vitro and ex vivo.
@en
Improved lymphocyte function-associated antigen-1
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Improved lymphocyte function-a ...... changes in vitro and ex vivo.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921