Requirements for DNA unpairing during displacement synthesis by HIV-1 reverse transcriptase.
about
Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateDNA-directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon.Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesisAnalysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H functionSubstitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.Single-molecule study of DNA polymerization activity of HIV-1 reverse transcriptase on DNA templates.
P2860
Q33381540-4905C501-7930-48D5-B5F2-937444099F21Q34007576-27191807-A155-40AF-B87A-06EB83043D60Q34559569-2B43B6BD-4AAB-46EB-AFD5-F97F40492C35Q34658171-79BB2DDB-E520-430A-94E0-D68DB130F015Q36098110-1F1CFDA3-E67E-4E00-B069-C8EDB467FB9CQ37278712-CFD5A0AD-99F5-4205-AC4C-A7DD85366FD8Q41954255-9377C649-F821-4D26-B854-8B5F422EDF6F
P2860
Requirements for DNA unpairing during displacement synthesis by HIV-1 reverse transcriptase.
description
2004 nî lūn-bûn
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Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@en
Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@nl
type
label
Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@en
Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@nl
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Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@en
Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@nl
P2093
P2860
P356
P1476
Requirements for DNA unpairing ...... y HIV-1 reverse transcriptase.
@en
P2093
Ben D Buelow
Benjamin A Paulson
James J Champoux
Jamie Winshell
P2860
P304
52924-52933
P356
10.1074/JBC.M409134200
P407
P577
2004-09-30T00:00:00Z