Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping.
about
The CRIT framework for identifying cross patterns in systems biology and application to chemogenomicsHuman AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalSystems biology approaches for discovering biomarkers for traumatic brain injuryIntegrative approaches for finding modular structure in biological networksTransfer RNA methytransferases and their corresponding modifications in budding yeast and humans: activities, predications, and potential roles in human healthA UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Gene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization toolReprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteinsGlobal analysis of condition-specific subcellular protein distribution and abundanceA systems approach to delineate functions of paralogous transcription factors: role of the Yap family in the DNA damage response.Novel roles for selected genes in meiotic DNA processing.A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-αA quantitative systems approach reveals dynamic control of tRNA modifications during cellular stressTrm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased TranslationMembrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiaeIdentification of novel human damage response proteins targeted through yeast orthology.The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.Protein damage by reactive electrophiles: targets and consequencesSystems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae.Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.A network of conserved damage survival pathways revealed by a genomic RNAi screen.Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks.Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae.A systems approach to mapping DNA damage response pathwaysIdentification of response-modulated genetic interactions by sensitivity-based epistatic analysis.Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cellsRegulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy numberGenome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposureExpression and functional profiling reveal distinct gene classes involved in fatty acid metabolism.High throughput screening identifies modulators of histone deacetylase inhibitorsThe protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity.Gcn5 Modulates the Cellular Response to Oxidative Stress and Histone Deacetylase Inhibition.Elucidating mechanisms of drug-induced toxicity.Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis.
P2860
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P2860
Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Hot spots for modulating toxic ...... ping and localization mapping.
@en
Hot spots for modulating toxic ...... ping and localization mapping.
@nl
type
label
Hot spots for modulating toxic ...... ping and localization mapping.
@en
Hot spots for modulating toxic ...... ping and localization mapping.
@nl
prefLabel
Hot spots for modulating toxic ...... ping and localization mapping.
@en
Hot spots for modulating toxic ...... ping and localization mapping.
@nl
P2093
P1433
P1476
Hot spots for modulating toxic ...... ping and localization mapping.
@en
P2093
Ari S Rosenbach
Leona D Samson
Thomas J Begley
Trey Ideker
P304
P356
10.1016/J.MOLCEL.2004.09.005
P577
2004-10-01T00:00:00Z