Drug uptake pathways of multidrug transporter AcrB studied by molecular simulations and site-directed mutagenesis experiments.
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Recent advances toward a molecular mechanism of efflux pump inhibitionStructural basis of RND-type multidrug exportersGenetic assessment of the role of AcrB β-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump of Escherichia coliHierarchical domain-motion analysis of conformational changes in sarcoplasmic reticulum Ca²⁺-ATPase.AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosaStepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.An overview of bacterial efflux pumps and computational approaches to study efflux pump inhibitors.MexY-promoted aminoglycoside resistance in Pseudomonas aeruginosa: involvement of a putative proximal binding pocket in aminoglycoside recognition.Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrBRandom mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitorsSwitch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporterDynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface.Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.Molecular Determinants of the Promiscuity of MexB and MexY Multidrug Transporters of Pseudomonas aeruginosa.Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force
P2860
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P2860
Drug uptake pathways of multidrug transporter AcrB studied by molecular simulations and site-directed mutagenesis experiments.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@en
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@nl
type
label
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@en
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@nl
prefLabel
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@en
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@nl
P356
P1476
Drug uptake pathways of multid ...... ected mutagenesis experiments.
@en
P2093
Nobuhiro Kimura
Shoji Takada
P304
P356
10.1021/JA310548H
P407
P577
2013-05-14T00:00:00Z