Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
about
Efficient trapping of HIV-1 envelope protein by hetero-oligomerization with an N-helix chimera.Fine-tuning multiprotein complexes using small moleculesFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinitySolution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrateCrystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System: INSIGHT INTO INTERMOLECULAR COMMUNICATIONAggresome formation and neurodegenerative diseases: therapeutic implicationsEctoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloidAllostery in Hsp70 chaperones is transduced by subdomain rotationsFactor V activator from Daboia russelli russelli venom destabilizes β-amyloid aggregate, the hallmark of Alzheimer disease.A synergistic small-molecule combination directly eradicates diverse prion strain structuresCombining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.Abeta42 mutants with different aggregation profiles induce distinct pathologies in DrosophilaAmyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library.Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate.Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.Ovine colostrum nanopeptide affects amyloid beta aggregation.Phenol red interacts with the protofibril-like oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts.Isolation and characterization of antibody fragments selective for toxic oligomeric tauFew-layer bismuth selenides exfoliated by hemin inhibit amyloid-β1-42 fibril formation.Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35.Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization.Pharmacogenomics and therapeutic prospects in Alzheimer's disease.New prospects and strategies for drug target discovery in neurodegenerative disordersFree energies of protein-protein association determined by electrospray ionization mass spectrometry correlate accurately with values obtained by solution methodsNovel therapeutic strategies for the treatment of protein-misfolding diseases.FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivoPharmacological targeting of the Hsp70 chaperone.Applying Hsp104 to protein-misfolding disorders.Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.Emergence and natural selection of drug-resistant prions.Biomolecular engineering of intracellular switches in eukaryotesProtein tango: the toolbox to capture interacting partners.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseProtein quality control system in neurodegeneration: a healing company hard to beat but failure is fatal.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation.Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.
P2860
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P2860
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@en
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@nl
type
label
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@en
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@nl
prefLabel
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@en
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@nl
P2093
P356
P1433
P1476
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
@en
P2093
Gerald R Crabtree
Isabella A Graef
Jason E Gestwicki
P304
P356
10.1126/SCIENCE.1101262
P407
P577
2004-10-01T00:00:00Z