Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
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The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar ratsRole of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motilityEvaluation of the use of therapeutic peptides for cancer treatmentInherited predisposition to glioma.Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53, CDKN2A and N-Ras genes.Tumor suppression by p53: making cells senescent.Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells.Gene therapy for malignant glioma.Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 5: apoptosis and cell cycle.A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor.p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cellsStrategies in gene therapy for glioblastoma.Viruses, gene therapy and stem cells for the treatment of human glioma.p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences.Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes.p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways.Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior.p16(ink4a) and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG-A astrocytoma cells.MiRNA-mediated tumor specific delivery of TRAIL reduced glioma growth.Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo.BCL-2 promotes migration and invasiveness of human glioma cells.Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.The role of matrix metalloproteinases in the pathophysiology and progression of human nervous system malignancies: a chance for the development of targeted therapeutic approaches?
P2860
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P2860
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@en
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@nl
type
label
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@en
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@nl
prefLabel
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@en
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@nl
P2093
P356
P1433
P1476
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
@en
P2093
Bjerkvig R
Chintala SK
Gomez-Manzano C
Kyritsis AP
Venkaiah B
P2888
P304
P356
10.1038/SJ.ONC.1201382
P407
P577
1997-10-01T00:00:00Z
P5875
P6179
1027492723