An in silico approach to discovering novel inhibitors of human sirtuin type 2.
about
Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsIdentification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulationsRejuvenating sirtuins: the rise of a new family of cancer drug targetsComparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families.Class II histone deacetylases: from sequence to function, regulation, and clinical implication.The Identification of a SIRT6 Activator from Brown Algae Fucus distichusStructure-based development of novel sirtuin inhibitors.Identification and characterization of novel sirtuin inhibitor scaffoldsDesign of a novel nucleoside analog as potent inhibitor of the NAD dependent deacetylase, SIRT2Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2)In silico pharmacology for drug discovery: applications to targets and beyondA comprehensive view of polyamine and histamine metabolism to the light of new technologies.The therapeutic uses of chromatin-modifying agents.Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula.Sirtuin inhibitors.Histone deacetylase inhibitors (HDACIs). Structure--activity relationships: history and new QSAR perspectives.Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview.Sirtuin inhibitors as anticancer agents.A chemical probe toolbox for dissecting the cancer epigenome.Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.CobB1 deacetylase activity in Streptomyces coelicolor.Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors.Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+dependent histone deacetylase Sirt2Computer- and Structure-Based Lead Identification for Epigenetic Targets
P2860
Q24613541-F1058905-CE84-481C-825E-54DFF17B5860Q28485339-3BECA01F-46A2-4947-9008-A237A81FE6AFQ30570951-C8DA5591-6A2D-45D3-B152-2A97450D9D0EQ30886620-1F0F1EEF-06DC-4ED1-87CC-67779D8FE038Q33724483-E12353CF-FF0B-4B11-85CC-3C6B10407167Q33833447-2CC67213-5417-415E-B42B-B62E30DD9C6EQ34027182-CF8CE721-3A30-4E65-A377-FF07C0F80C9EQ34088797-6C112FD1-28C0-4B84-A92C-AC6D41DBE332Q34729139-7316EDCA-1BE1-47DA-848D-976045CAD0E1Q35252505-5CF0FF0D-B6A4-4139-8949-98F71354BAEAQ35889785-B4481570-5C80-4BFD-8891-D8FC30B1488FQ35995265-293D7957-36EA-46E1-8D61-782AD86FFE8CQ36346498-983E2DEA-8849-412F-B57C-A0EF965AC7CCQ36822457-7A6A6E19-7FA0-416B-A3FF-8653A6B0CF3CQ37114055-D1659045-66E5-4351-9443-F7AA743BB0ACQ37329348-947ACDA1-5746-4D59-B89B-B77E199CDB63Q37481259-B533ED5B-CA65-49CE-BCEA-08841645777AQ37693855-3DCB023B-B5A8-4160-87DD-82809D1E2A3DQ37946239-66D54F03-4E15-4D64-A22B-2277401DE661Q38223016-D75EAEA9-1BF7-43EB-AFE0-E7AD1E2C4C6FQ39147132-12DB6348-381A-495C-96C1-E0D2067326C5Q41697166-9FAA0D88-8EC6-44CB-B9C4-F0D083B43A4EQ45895655-E4994720-C1AE-4738-AD5B-28A08BF0AFBCQ47417068-B9E4A438-A28C-45D0-A9DB-D04DF76538FAQ53113048-1913C955-29B6-44D3-A970-FAA5D28D3D90Q58860073-38B108A9-6C96-43BD-8C86-6B1BB2804436Q58860105-8A96F1A1-5159-4DC5-A20A-D4414E5B9BAC
P2860
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@en
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@nl
type
label
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@en
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@nl
prefLabel
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@en
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@nl
P2093
P356
P1476
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
@en
P2093
Antero Salminen
Anu J Tervo
Jukka Leppänen
Päivi Niskanen
Sergiy Kyrylenko
Tomi Järvinen
P304
P356
10.1021/JM049933M
P407
P577
2004-12-01T00:00:00Z