Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
about
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's diseaseInhibition of IAPP Aggregation and Toxicity by Natural Products and DerivativesSmall-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's diseaseBinding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current statusInteractions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assemblyMolecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Differentiating Alzheimer disease-associated aggregates with small molecules.Fluorescence quantum yield of thioflavin T in rigid isotropic solution and incorporated into the amyloid fibrils.Molecular polymorphism of Abeta in Alzheimer's disease.A role for amyloid in cell aggregation and biofilm formation.PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease.Probing small molecule binding to amyloid fibrils.Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer's disease pathologies.Analyzing thioflavin T binding to amyloid fibrils by an equilibrium microdialysis-based technique.Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infectionInhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.Intravenous delivery of targeted liposomes to amyloid-β pathology in APP/PSEN1 transgenic mice.On the origin of the stronger binding of PIB over thioflavin T to protofibrils of the Alzheimer amyloid-β peptide: a molecular dynamics study.Tritium-labeled (E,E)-2,5-bis(4'-hydroxy-3'-carboxystyryl)benzene as a probe for β-amyloid fibrilsPhenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengersInsight into amyloid structure using chemical probes.Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer's diseaseA molecular tweezer antagonizes seminal amyloids and HIV infection.Stoichiometry and Affinity of Thioflavin T Binding to Sup35p Amyloid Fibrils.Synthesis and in vitro evaluation of α-synuclein ligands.Ligand electronic properties modulate tau filament binding site densityIn vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.Strategies for molecular imaging dementia and neurodegenerative diseases.What amyloid ligands can tell us about molecular polymorphism and disease.Modulation and detection of tau aggregation with small-molecule ligandsSmall-molecule mediated neuroprotection in an in situ model of tauopathy.A review of imaging agent development.The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulationsFluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease.Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.Alzheimer's disease and the amyloid-beta peptide.Amyloid-β probes: Review of structure-activity and brain-kinetics relationships.Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Small bifunctional chelators that do not disaggregate amyloid β fibrils exhibit reduced cellular toxicity.Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.
P2860
Q24305330-24D4B4C6-89AD-4398-94A5-CB03E4AE5BD1Q27013875-CFD6873F-F27E-4156-82E6-2E6CFFDECFD9Q27309046-66D6FF62-D9BB-4059-B237-C8580DD81F68Q28393352-BFE3EC19-D07F-43C9-A7BA-A2A2CA7D3532Q28910341-483833B8-9FB2-4779-9D01-4656745E7E85Q31047131-96BC2FC0-97C6-477A-82ED-B68137C77470Q33296123-07D8754F-6B3F-4009-84AF-F6E84F829FC5Q33737447-94B62377-E604-4B74-8C1C-5C1C43584AB4Q33741493-1586B0F1-351E-46E3-B2DA-0D964A891190Q33847424-B4D0F386-43B7-4A6C-A884-FEE32F0F4318Q33936595-14A1E0FD-D529-4111-8A54-C99CBB8E09BBQ34050053-8E29E31E-6170-4339-AED1-D49183A4D463Q34102715-7EB0DC7B-001B-4241-AB62-8BB5AF500AE8Q34181516-F143B113-99FA-4639-8AAD-F2CD56618B69Q34285096-BB81D551-7B24-48E5-A256-AA2F02FD816FQ34385820-2927B69F-8358-4349-AA73-A66EE93283BDQ34465222-A381275B-74B9-446F-9813-DC1F0AF8D50DQ34594635-B249ED30-3F38-4C61-BA50-D25D825A67A0Q34625450-E930BC5A-0C05-4C44-A789-8F16C407115CQ34674252-302A0404-A1F9-4D93-A48C-A8774A9650EAQ34990429-E97828A8-3064-46E1-BF05-479193F44025Q35772537-F172ED08-57AC-4417-9BEE-B649B52C9246Q35954283-3F766D14-ECF9-4771-AD13-112036D45260Q36030781-7A8AFC21-5E61-41A6-856D-AB96D9B19DA4Q36106447-E46C1502-9390-4918-AAC9-926A7F84C41DQ36368413-E351DFEF-005F-488A-82BF-31E0114033ABQ36691547-04216ECE-CCBE-408D-80E8-364A2A13A885Q36853915-C3277A70-3F49-4B15-99AD-CF82AB4494DBQ36871202-D8790813-5B70-43B9-BE79-8ABA3EBDC1B7Q37050216-949FC08E-BC37-46CA-9D3E-166F6EE9AF77Q37087223-AC249BFD-BEE2-44DC-B450-B286646144F5Q37214528-85B7F620-10BB-495B-8F56-7C17889EDD0DQ37266621-94C22039-ECB9-4AE7-8FED-4D83C87AB642Q37386143-EB18AE46-B8A5-4969-AFBE-7B4AB8A343F6Q37498339-B75A8672-7F4B-4C2E-A038-118B74DEDD31Q37671455-DC4CD4E2-4372-439B-97E4-C83560106A8BQ38114434-0881219B-5F92-4120-9973-A568CE8E08F2Q38199617-227B603E-5331-4272-8DE7-771358DF1860Q38946116-7C850EBE-FD3F-48AC-B214-1D6A4B0AD482Q38946925-80884FB6-4ABC-404A-9CC9-12127CAAF577
P2860
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@en
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@nl
type
label
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@en
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@nl
prefLabel
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@en
Evidence for the presence of t ...... beta-amyloid peptide fibrils.
@nl
P2093
P2860
P356
P1476
Evidence for the presence of t ...... n beta-amyloid peptide fibrils
@en
P2093
Andrew Lockhart
Andy T Merritt
Duncan B Judd
Guizhu Hong
Jennifer L Morgenstern
John Brown
Peter N Lowe
P2860
P304
P356
10.1074/JBC.M412056200
P407
P50
P577
2004-12-21T00:00:00Z