Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. - Wikidata - awgldk - TriplyDB

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.

http://www.wikidata.org/entity/Q45228618

about

Phosphoinositides: tiny lipids with giant impact on cell regulation A key role for the phosphorylation of Ser440 by the cyclic AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5'-phosphatase (SHIP1).Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinase Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8 Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.Interleukin-10 inhibits lipopolysaccharide induced miR-155 precursor stability and maturation Discovery and development of small molecule SHIP phosphatase modulators.Lipid Signaling in Tumorigenesis.Inositol phospholipid signaling and the biology of natural killer cells.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway.INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo.New concepts in chronic urticaria.Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.Understanding the mechanisms of anaphylaxis.Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation.Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.IgE-dependent signaling as a therapeutic target for allergies.The chemical biology of phosphoinositide 3-kinases.Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy.Role of inositol phospholipid signaling in natural killer cell biology.Role of SHIP1 in cancer and mucosal inflammation.Neutrophil migration: moving from zebrafish models to human autoimmunity.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.

P2860

Q27012953-177AF062-DE88-442E-8159-43CC8D8F0D09 Q30429837-757656FD-8CAB-42D7-A1F7-D7A6B711FE75 Q30435403-C6F1D46F-6328-495A-976C-707BAFA72843 Q33493174-DCD1AC5E-0B74-41CB-B7E2-B4EAB988D85A Q33808094-172AECC8-7B31-4A4A-8A7A-04A35E6EA1F6 Q33824783-8EA44BBC-5868-4620-A598-B38593556DF6 Q33926879-D48B303E-A5F4-43AC-96DD-34871DF05B54 Q34024558-2FBAE485-F2FB-40BE-93FB-D3201E052E0E Q34212404-FDCDC1C8-B359-4655-95CA-64DF6783B4DC Q34262292-38652CFC-2EA9-481E-AB4B-EBCBE0E56DCA Q34405336-CE072B77-0E58-48C1-AC3D-E870058EA9A4 Q34499276-95CC6BCC-8278-4D01-ADD7-4D05FC9F32BC Q34949325-41525D63-1FD3-4D2A-A981-5D59C4B9D9BC Q35058356-7476EF57-A3F0-4E49-89E2-BF9904E3BC10 Q35136532-2D2300C4-A837-4335-9B78-AE6CA5598166 Q35559739-1DB7F5A1-DF10-4B6C-8050-72BF6225320E Q36150234-6101DED2-64AA-4E73-B19A-2A36FFD10B9B Q36286414-4859F060-386C-4BB2-BDEC-2813ACD0992C Q36368266-1FB57DF1-572E-46C3-B1C8-9B884BE52C99 Q36545503-ED02F1B6-E2FB-41FA-9A59-2342B66F32FF Q36588627-0F5523FA-D05E-488B-BF1E-C5F6C4FE67D8 Q36603122-5A45128D-2D0B-4478-9FF6-5F34FF88023D Q36652026-EAAE8B88-11B8-4162-B6B8-38B76BC26509 Q36681799-8A58AAED-7D50-4FD7-A725-78B8E6A08C1E Q36681804-8FACC586-6FB0-4290-9B11-50A724128DB9 Q37029360-61FD8FC4-9AB8-4CC4-8E69-BB6753190BB5 Q37029553-D978C5EE-2AAB-468F-8471-E7423BAAC789 Q37066101-3DCF54D8-0EAF-42F0-856A-3CC087C6316E Q37195584-C90F3267-C34C-4533-8BEE-91C2B04701C1 Q37594369-4E030E25-9801-41EB-924E-CBC2D780CEFB Q37642294-5F0263C8-4B9C-47DD-992D-B1ADC1D30FC5 Q37820689-93C88B21-8B07-423F-AA14-1088BC0EE10D Q37989699-138EAD81-F559-418A-AAD9-D3ACEEECE846 Q38022997-C7BC05A6-8032-427C-AC30-26162FC69566 Q38042382-6708AFD8-C1A8-494E-8DA9-EE70F3475137 Q38051310-1F5DD476-93EA-4B0E-8164-9B2B665A8059 Q38090984-C5677508-8D1C-42EE-A9BD-BE444F6FF000 Q38095570-761DE2A7-C5FA-44BE-A21A-8DC95BE0A870 Q38151856-E0B0E5D3-14FA-459B-A9D2-7900A592F96D Q38755941-181330CC-C57B-4DD5-9611-F0ED9B93EFEA

P2860

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.

http://www.wikidata.org/entity/Q45228618

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh-hant

name

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@en

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@nl

type

label

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@en

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@nl

prefLabel

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@en

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@nl

P1433

Q45228618-9E16C952-B9E1-41B0-9DD7-2F4600AE139F

P1476

Q45228618-768A23CB-551D-468D-9739-08B2C47E819D

P2093

Q45228618-34BF4F20-ED76-4B99-B7FF-58F31268B582

Q45228618-55B6F304-46E3-432A-95BA-CAB6AE762A86

Q45228618-5E6D7796-F036-46CD-8E2D-AC954E0E1123

Q45228618-7134664E-CC24-4C1D-B273-D1DFB1A3837F

Q45228618-87D1F7E8-7139-4584-B586-7C64DCB0D629

Q45228618-89107D5E-18CB-4A58-BFC4-70035CE754CD

Q45228618-9447CB4C-E4C9-4E00-AF94-0C9325E3FEC4

Q45228618-9703B3D7-6C49-45B0-A3C2-9D5DE193BBE9

Q45228618-985F6417-13F4-4E33-A984-54E6F5AA1693

Q45228618-99E81D13-752B-4B72-A9B9-A7F850E65A76

P304

Q45228618-41C6396F-4546-4B8A-8C02-A456C29D16DC

P31

Q45228618-8154A4E5-0D43-433A-B028-72095FEF0464

P356

Q45228618-2EF62F9A-1E9A-4A89-93D6-CA52005B2561

P407

Q45228618-44A71ED3-AE48-4232-BA90-82E011C65885

P433

Q45228618-8821D971-C88D-43D0-9A5A-5765AC6AEA24

P478

Q45228618-5F99AA18-2A4C-45FF-9576-D94B1A6042B5

P577

Q45228618-A1741422-0914-49A1-ADC7-F2806614DF7C

P5875

Q45228618-44E9E4C1-5AEB-4C1C-B716-C3A74C76D79F

P698

Q45228618-3CE77C60-72B1-433F-94C4-45DB87A614B4

P356

BLOOD-2007-03-079699

P1433

P1476

Small-molecule agonists of SHI ...... athway in hematopoietic cells.

@en

P2093

Ali Ghanipour

http://www.w3.org/2001/XMLSchema#string

Alice L-F Mui

http://www.w3.org/2001/XMLSchema#string

Andrew Ming-Lum

http://www.w3.org/2001/XMLSchema#string

Christopher J Ong

http://www.w3.org/2001/XMLSchema#string

David E Williams

http://www.w3.org/2001/XMLSchema#string

Gerald Krystal

http://www.w3.org/2001/XMLSchema#string

Jens Ruschmann

http://www.w3.org/2001/XMLSchema#string

Joseph Kim

http://www.w3.org/2001/XMLSchema#string

Kewei Ma

http://www.w3.org/2001/XMLSchema#string

Li-Ping Cao

http://www.w3.org/2001/XMLSchema#string

P304

1942-1949

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2007-03-079699

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

110

http://www.w3.org/2001/XMLSchema#string

P577

2007-05-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6330601

http://www.w3.org/2001/XMLSchema#string

P698

17502453

http://www.w3.org/2001/XMLSchema#string