Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.
about
Systems biology and biomarkers of early effects for occupational exposure limit settingConsiderations for using genetic and epigenetic information in occupational health risk assessment and standard settingThe next generation of risk assessment multiyear study - highlights of findings, applications to risk assessment, and future directionsCurrent perspectives on the use of alternative species in human health and ecological hazard assessmentsNovel in vitro and mathematical models for the prediction of chemical toxicityBig data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicantsEvolution of a Structure-Searchable Database into a Prototype for a High-Fidelity SmartPhone App for 62 Common Pesticides Used in DelawareAddressing human variability in next-generation human health risk assessments of environmental chemicalsCERAPP: Collaborative Estrogen Receptor Activity Prediction ProjectIncorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.Predictive model of rat reproductive toxicity from ToxCast high throughput screening.Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput in vitro Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling.Using In Vitro High-Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards.Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.Future challenges to protecting public health from drinking-water contaminants.A framework for the next generation of risk science.Prioritizing chemicals and data requirements for screening-level exposure and risk assessmentPopulation-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.A framework incorporating the impact of exposure scenarios and application conditions on risk assessment of chemicals applied to skin.International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposesStage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics.Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.Quantitative high-throughput screening for chemical toxicity in a population-based in vitro modelToxicokinetic Triage for Environmental Chemicals.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches.Intake to production ratio: a measure of exposure intimacy for manufactured chemicals.Advancing the next generation of health risk assessmentIn vitro screening for population variability in toxicity of pesticide-containing mixturesAddressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation.Improving the human hazard characterization of chemicals: a Tox21 updateRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards.FutureTox: building the road for 21st century toxicology and risk assessment practicesDevelopmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study.Critical consideration of the multiplicity of experimental and organismic determinants of pyrethroid neurotoxicity: a proof of concept.Mammalian toxicology and human exposures to the flame retardant 2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol (TBBPA): implications for risk assessment.
P2860
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P2860
Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Estimating toxicity-related bi ...... hput chemical risk assessment.
@en
Estimating toxicity-related bi ...... hput chemical risk assessment.
@nl
type
label
Estimating toxicity-related bi ...... hput chemical risk assessment.
@en
Estimating toxicity-related bi ...... hput chemical risk assessment.
@nl
prefLabel
Estimating toxicity-related bi ...... hput chemical risk assessment.
@en
Estimating toxicity-related bi ...... hput chemical risk assessment.
@nl
P2093
P50
P356
P1476
Estimating toxicity-related bi ...... hput chemical risk assessment.
@en
P2093
Barbara A Wetmore
David J Dix
Elaine A Cohen Hubal
Keith A Houck
R Woodrow Setzer
Robert J Kavlock
Thomas B Knudsen
P304
P356
10.1021/TX100428E
P577
2011-03-08T00:00:00Z