The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.
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Neuropharmacology of alcohol addictionGlutamatergic substrates of drug addiction and alcoholismmGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsDissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcerNegative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowGlutamatergic targets for new alcohol medicationsTargeting glutamate uptake to treat alcohol use disordersA Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.Glutamatergic transmission in drug reward: implications for drug addictionUnderstanding how the brain perceives alcohol: neurobiological basis of ethanol discriminationDifferential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P ratsEthanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validityNucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescentsInvolvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbensMetabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intakeEffects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependenceThe mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats.The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system.Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinkingMetabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in ratsSynaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primatesCritical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawalInteractive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in ratsFrequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathwaysmGlu receptors and drug addiction.Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats.Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.
P2860
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P2860
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The mGluR5 antagonist MPEP dec ...... n alcohol-preferring (P) rats.
@en
The mGluR5 antagonist MPEP dec ...... ivations in alcohol-preferring
@nl
type
label
The mGluR5 antagonist MPEP dec ...... n alcohol-preferring (P) rats.
@en
The mGluR5 antagonist MPEP dec ...... ivations in alcohol-preferring
@nl
prefLabel
The mGluR5 antagonist MPEP dec ...... n alcohol-preferring (P) rats.
@en
The mGluR5 antagonist MPEP dec ...... ivations in alcohol-preferring
@nl
P1433
P1476
The mGluR5 antagonist MPEP dec ...... in alcohol-preferring (P) rats
@en
P2093
David H Overstreet
Jason P Schroeder
P2888
P304
P356
10.1007/S00213-005-2175-9
P577
2005-02-17T00:00:00Z
P6179
1030943480