about
Can animal models of disease reliably inform human studies?Publication bias in reports of animal stroke studies leads to major overstatement of efficacyA combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validationA call for transparent reporting to optimize the predictive value of preclinical researchInsertion of an extra codon for threonine is a cause of dihydropteridine reductase deficiencyStem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studiesEvaluation of combination therapy in animal models of cerebral ischemiaA concerted appeal for international cooperation in preclinical stroke researchMeta-analysis of data from animal studies: a practical guide.Salvaging the ischaemic penumbra: more than just reperfusion?Pooling of animal experimental data reveals influence of study design and publication bias.Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats.Characterization of fluoromisonidazole binding in stroke.Isolating cells from non-sperm cellular mixtures using the PALM microlaser micro dissection system.A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis.Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically.Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing.An enriched environment improves sensorimotor function post-ischemic stroke.Inducing stroke in aged, hypertensive, diabetic rats.A systematic review and meta-analysis of erythropoietin in experimental stroke.Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemiaACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activityThe benefit of hypothermia in experimental ischemic stroke is not affected by pethidine.Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysisHypothermia protects human neurons.'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISOEvidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality.Evaluation of excess significance bias in animal studies of neurological diseasesSystematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injuryMeta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressureCNS regeneration: clinical possibility or basic science fantasy?Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke.Ischaemic tolerance and mitochondrial uncoupling--can we learn from the cell?Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke.Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trialsReduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot studyInflammation following stroke.A novel population of α-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemiaHypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David Howells
@ast
David Howells
@en
David Howells
@es
David Howells
@nl
David Howells
@sl
type
label
David Howells
@ast
David Howells
@en
David Howells
@es
David Howells
@nl
David Howells
@sl
altLabel
D W Howells
@en
David William Howells
@en
Professor David William Howells
@en
prefLabel
David Howells
@ast
David Howells
@en
David Howells
@es
David Howells
@nl
David Howells
@sl
P106
P21
P31
P496
0000-0002-2512-7724