Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability.
about
Optimization of heavy chain and light chain signal peptides for high level expression of therapeutic antibodies in CHO cellsAn internal ribosome entry site (IRES) mutant library for tuning expression level of multiple genes in mammalian cells.Synthetic promoters for CHO cell engineering.Direct analysis of mAb aggregates in mammalian cell culture supernatant.Efficient Production of a Bioactive Bevacizumab Monoclonal Antibody Using the 2A Self-cleavage Peptide in Transgenic Rice Callus.New Mammalian Expression Systems.State of play and clinical prospects of antibody gene transfer.A simple method to determine IgG light chain to heavy chain polypeptide ratios expressed by CHO cells.Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design.Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells.Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells.Evaluation of different vector design strategies for the expression of recombinant monoclonal antibody in CHO cells.Multigene expression in stable CHO cell pools generated with the piggyBac transposon system.Impact of Signal Peptides on Furin-2A Mediated Monoclonal Antibody Secretion in CHO Cells.Strategies and Considerations for Improving Expression of "Difficult to Express" Proteins in CHO Cells.Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.IgG Aggregation Mechanism for CHO Cell Lines Expressing Excess Heavy Chains.Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.
P2860
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P2860
Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Control of IgG LC:HC ratio in ...... and conformational stability.
@en
Control of IgG LC:HC ratio in ...... and conformational stability.
@nl
type
label
Control of IgG LC:HC ratio in ...... and conformational stability.
@en
Control of IgG LC:HC ratio in ...... and conformational stability.
@nl
prefLabel
Control of IgG LC:HC ratio in ...... and conformational stability.
@en
Control of IgG LC:HC ratio in ...... and conformational stability.
@nl
P2093
P1476
Control of IgG LC:HC ratio in ...... and conformational stability.
@en
P2093
Corrine Wan
Esther Y C Koh
Miranda van Beers
Monika Mueller
Muriel Bardor
Steven C L Ho
Yen Wah Tong
Yuansheng Yang
Zhiwei Song
P304
P356
10.1016/J.JBIOTEC.2013.03.019
P577
2013-04-10T00:00:00Z