A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
about
Structural basis for elastolytic substrate specificity in rodent alpha-chymasesGeneration, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domainMolecular modeling study for inhibition mechanism of human chymase and its application in inhibitor designA combination of receptor-based pharmacophore modeling & QM techniques for identification of human chymase inhibitorsGuinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidasesMast cell peptidases: chameleons of innate immunity and host defense.The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black: Focus on Oxidative Stress and Inflammatory PathwaysNeutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Mast cell proteases as pharmacological targetsAn evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach.3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors.Gene expression profiling in human asthmaNeutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.Fragment oriented molecular shapesTreating COPD with PDE 4 inhibitors.Mast cell proteases as protective and inflammatory mediators.Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?Inhibitors of cathepsin G: a patent review (2005 to present).In silico approach to find chymase inhibitors among biogenic compounds.Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris.Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates.Novel diphenyl esters of peptidyl alpha-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin.Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.Computational studies of novel chymase inhibitors against cardiovascular and allergic diseases: mechanism and inhibition.Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease
P2860
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P2860
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@en
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@nl
type
label
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@en
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@nl
prefLabel
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@en
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@nl
P2093
P2860
P356
P1476
A novel, potent dual inhibitor ...... inflammatory activity in vivo.
@en
P2093
Agustin O Pineda
Annette J Eckardt
Barbara J Haertlein
Bruce E Maryanoff
Bruce P Damiano
Claudia K Derian
Edward C Giardino
Enrico Di Cera
F Scott Mathews
Grace I Wells
P2860
P304
18001-18007
P356
10.1074/JBC.M501302200
P407
P577
2005-02-28T00:00:00Z