Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters.
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Corticostriatal Dysfunction in Huntington's Disease: The BasicsThe Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and SenescenceChronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Dopamine Receptors and NeurodegenerationRole of cerebral cortex in the neuropathology of Huntington's diseaseCurrent approaches to enhance glutamate transporter function and expressionN-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's diseaseDistinct pools of non-glycolytic substrates differentiate brain regions and prime region-specific responses of mitochondriaDecreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.Neurochemical correlates of caudate atrophy in Huntington's disease.In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease.Mapping pathological phenotypes in reelin mutant mice.Therapeutic approaches to preventing cell death in Huntington diseaseNeuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy.Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's diseaseUp-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease.Potential drugs and methods for preventing or delaying the progression of Huntington's disease.Aging of the NMDA receptor: from a mouse's point of viewEarly exposure to dynamic environments alters patterns of motor exploration throughout the lifespan.Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDPGenetic mouse models of Huntington's disease: focus on electrophysiological mechanisms.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington's disease: interactions between neurons and astrocytes.Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.The role of glial-specific Kir4.1 in normal and pathological states of the CNS.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Dysregulation of corticostriatal ascorbate release and glutamate uptake in transgenic models of Huntington's disease.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex.
P2860
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P2860
Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
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2009年學術文章
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name
Glutamate toxicity in the stri ...... els of glutamate transporters.
@en
Glutamate toxicity in the stri ...... els of glutamate transporters.
@nl
type
label
Glutamate toxicity in the stri ...... els of glutamate transporters.
@en
Glutamate toxicity in the stri ...... els of glutamate transporters.
@nl
prefLabel
Glutamate toxicity in the stri ...... els of glutamate transporters.
@en
Glutamate toxicity in the stri ...... els of glutamate transporters.
@nl
P2093
P1476
Glutamate toxicity in the stri ...... els of glutamate transporters.
@en
P2093
Ana María Estrada-Sánchez
José Segovia
Lourdes Massieu
Teresa Montiel
P356
10.1016/J.NBD.2008.12.017
P577
2009-01-09T00:00:00Z