TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.
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The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.
P2860
TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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2016年學術文章
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name
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@en
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@nl
type
label
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@en
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@nl
prefLabel
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@en
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@nl
P2093
P2860
P356
P1476
TAK-063, a Novel Phosphodieste ...... Model of Huntington's Disease.
@en
P2093
Akina Harada
Haruhide Kimura
Kazunori Suzuki
P2860
P356
10.1124/JPET.116.237388
P407
P577
2016-11-03T00:00:00Z