Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
about
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKRThe mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKRSuppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionHuntington's disease: the past, present, and future search for disease modifiers.Mechanisms of RNA-induced toxicity in CAG repeat disordersRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosismTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's diseaseInteraction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neuronsA genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's diseaseActivation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neuronsProteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.Long tract of untranslated CAG repeats is deleterious in transgenic miceRNA structure of trinucleotide repeats associated with human neurological diseases.Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase.Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.The role of the immune system in triplet repeat expansion diseasesStructures of trinucleotide repeats in human transcripts and their functional implications.Triplet repeat RNA structure and its role as pathogenic agent and therapeutic targetPKR activation in neurodegenerative disease.Repetitive sequences that shape the human transcriptome.Deficient PKR in RAX/PKR Association Ameliorates Ethanol-Induced Neurotoxicity in the Developing CerebellumPKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's diseaseIdentifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.Repeat expansion diseases: when a good RNA turns bad.Clinical and molecular events in patients with Machado-Joseph disease under lamotrigine therapy.Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.PKR involvement in Alzheimer's diseaseCould PKR inhibition modulate human neurodegeneration?Regulation of mRNA Translation in Neurons-A Matter of Life and Death.Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis
P2860
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P2860
Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@en
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@nl
type
label
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@en
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@nl
prefLabel
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@en
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@nl
P2093
P356
P1476
Double-stranded RNA-dependent ...... and is activated in HD tissue.
@en
P2093
B A Cottrell
D E Bredesen
L M Ellerby
P304
P356
10.1093/HMG/10.15.1531
P577
2001-07-01T00:00:00Z