Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.
about
The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerInsulin receptor signaling in normal and insulin-resistant statesRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsStructural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated RasTissue-specific regulation and function of Grb10 during growth and neuronal commitment.The role of genomic imprinting in biology and disease: an expanding view.BACs as tools for the study of genomic imprinting.Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisComplementation hypothesis: the necessity of a monoallelic gene expression mechanism in mammalian development.Genome-wide survey of imprinted genes.Imprinted genes in placental growth and obstetric disorders.Regulation of growth and metabolism by imprinted genes.Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset.Genomic organization and control of the grb7 gene family.Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations.Somatic Cell Nuclear Transfer Followed by CRIPSR/Cas9 Microinjection Results in Highly Efficient Genome Editing in Cloned Pigs.Grb10 is a dual regulator of receptor tyrosine kinase signaling.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaPeg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.Footprints of recent selection and variability in breed composition in the Göttingen Minipig genome.DNA methylation variability at growth-related imprints does not contribute to overweight in monozygotic twins discordant for BMI.Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process.
P2860
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P2860
Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@en
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@nl
type
label
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@en
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@nl
prefLabel
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@en
Meg1/Grb10 overexpression caus ...... of the IGF1R and IR cascades.
@nl
P2093
P1476
Meg1/Grb10 overexpression caus ...... n of the IGF1R and IR cascades
@en
P2093
Atsuo Konishi
Fumitoshi Ishino
Hirosuke Shiura
Kaori Muguruma
Minesuke Yokoyama
Naoki Miyoshi
Noriko Wakisaka-Saito
Rika Suzuki
Shigeharu Wakana
Tomoko Kaneko-Ishino
P304
P356
10.1016/J.BBRC.2005.02.047
P407
P577
2005-04-01T00:00:00Z