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Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.NMR determination of the bioactive conformation of peloruside A bound to microtubules.Isolation and structural determination of a unique polysaccharide containing mannofuranose from the cell wall of the fungus Acrospermum compressum.Cell wall polysaccharides isolated from the fungus Neotestudina rosatii, one of the etiologic agents of mycetoma in man.Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods.Hevein domains: an attractive model to study carbohydrate-protein interactions at atomic resolution.Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods.Unraveling the interaction between the LPS O-antigen of Burkholderia anthina and the 5D8 monoclonal antibody by using a multidisciplinary chemical approach, with synthesis, NMR, and molecular modeling methods.Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.New inhibitors of angiogenesis with antitumor activity in vivo.Dextrans produced by lactic acid bacteria exhibit antiviral and immunomodulatory activity against salmonid viruses.Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3.Novel pH-Stable Glycoside Hydrolase Family 3 β-Xylosidase from Talaromyces amestolkiae: an Enzyme Displaying Regioselective Transxylosylation.Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods.Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.NMR experiments for the measurement of proton-proton and carbon-carbon residual dipolar couplings in uniformly labelled oligosaccharides.Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins.Exploring NMR methods as a tool to select suitable fluorescent nucleotide analogues.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations.Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydratesTemperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experimentsMolecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR ApproachesAvenues to Characterize the Interactions of Extended N-Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin CaseA Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis
P50
Q24644289-F3EFE6EA-5705-41B1-8309-8D50089FA0BDQ30607577-728B0F6E-1AAF-445C-B38D-11FC7FD0D0CAQ30655561-8284BD61-D9AE-4458-AAAD-44360E6F86A8Q31047880-C38F98B5-EE86-4D56-872A-C1323C693EE0Q31111325-59204405-63D9-4A84-9944-97A3C59AC599Q33412180-E1DE6504-0959-4C5C-B926-152C04DB731DQ33746537-F30EF944-FE7D-4C59-9B24-7FB9EC96D138Q36409421-6F6FCFA6-9396-4009-B126-D42EA037CA15Q36496023-2724DE20-3350-4B65-A7DD-39482259D8D2Q38305855-52D0234A-1AE0-463E-9EAE-BAD7D96CA889Q38307047-97EB629F-6EED-4178-8211-ADDA281DCC72Q38309317-B5E837C2-8207-4E68-9679-A7698869E14AQ38310289-23107AE6-1428-40E2-A3A1-ECAABB1FD3BCQ38313957-1191979A-F8C2-4C6D-95CC-63BE1412CD21Q38331843-0B03B105-312C-4296-BBBD-6218E54ABEAAQ38701316-8C5BD924-1C4D-457E-B14B-3208F1BE2D98Q38752260-4F7095CC-5C4F-468C-B8EE-F2D3161F5D96Q38883150-3684235B-A2E6-4843-8FDA-95B5C651A30DQ38891251-128C1A57-296C-42C4-B91D-614C2C8F13C5Q38973142-59A5D7FC-3964-4A53-9568-3ECF8C6C392DQ39399206-E8410476-9082-430E-9B09-D75F35895816Q39876293-4FF4D45F-D011-491A-A443-6E16E46468ABQ42675058-9AF8397F-52C7-41BA-BC68-2D9177E77A4FQ45310156-9C762709-AF41-4345-9A96-E572D8EA0F7DQ46444962-6E4BC7BE-BF6A-41FC-B860-C599FE65C93CQ47163099-551723CA-A4BE-4987-9BD3-B343BA0BF44EQ47819381-11ADD113-E9F5-44B0-80D4-483A867F692AQ47837588-2B817015-57C9-449D-9798-E6C898A92A9EQ48030954-6D563574-7ADA-47D5-860C-D35C74D90BBDQ48198158-448D141C-B6AC-4A08-AB2D-A6C5E84D868CQ48765640-B67CD6AD-6725-4E15-BA90-D5B7998D66B7Q50043559-22098DA1-B2D3-48DF-A8E0-016788D2B02CQ51569908-064C86BD-327D-4FD8-B70B-75F9EE9F698DQ53093277-0645B05C-D189-42EC-BDB9-3B0FD1C4DCF5Q54427361-D234DA50-2E77-4DAD-9711-0402F6E1E307Q57515380-F9BC976A-4AB7-48C5-9E33-3E8112138C8BQ57946090-793BE25B-D393-4156-90C8-87D741E78240Q57966417-B5F64CF8-5857-4904-A561-8B65E3868E9FQ59352232-69136FC6-4436-4CE2-9E43-4B7B24B334A5Q60696468-0807FB1E-10C9-4D5B-BC96-18CAB3FA1B2D
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Angeles Canales
@ast
Angeles Canales
@en
Angeles Canales
@es
Angeles Canales
@nl
Angeles Canales
@sl
type
label
Angeles Canales
@ast
Angeles Canales
@en
Angeles Canales
@es
Angeles Canales
@nl
Angeles Canales
@sl
prefLabel
Angeles Canales
@ast
Angeles Canales
@en
Angeles Canales
@es
Angeles Canales
@nl
Angeles Canales
@sl
P1053
K-7499-2015
P106
P21
P31
P496
0000-0003-0542-3080