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Constitutive phosphorylation by pERK1/2Constitutive phosphorylation by GSK3p-S303;307-HSF1 binds YWHAE (14-3-3)MAPKAPK2 phosphorylates HSF1RPA1 binds HSF1DBC1 is phosphorylated by ATM/ARTDBC1 binds SIRT1SIRT1 binds to HSF1SIRT1 deacetylates HSF1HSP40s activate intrinsic ATPase activity of HSP70s in the cytosolHSP110s exchange ATP for ADP on HSP70s:ADPHikeshi binds HSP70s:ATPNPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasmHSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
P361
Q50286618-34FB22CD-99E3-4DE4-B0B2-3224BA685E12Q50286619-F7F049FB-0584-4F68-871B-A4356ECDC069Q50286621-58DC8C39-F9EA-4998-87F7-0B84E253A28BQ50286622-E1DB01B7-0D18-4197-B2F1-EE6384CEA4DFQ50286623-14859BF5-4356-4181-B683-7CE334C490BFQ50286625-16A8A94E-29FA-4A22-BF5A-120AE8F5D21AQ50286626-2B4B2ED7-FE86-489D-9D98-C15BBA85C149Q50286627-B66E8E15-7F1F-4859-80B3-64C049033936Q50286628-9745598B-3177-41C1-99A3-EBD20ACD2721Q50286629-CC6207B5-F791-4715-B20B-8F364C7E1741Q50286630-07EB0919-386A-42A2-867C-478AAE065178Q50286631-E173771B-CAAB-43D0-9FA3-B58C1B7F824FQ50286632-AF909812-5505-4BC2-9181-2EAEFBF85C5EQ50286633-74E9B0F3-5C23-4279-87C0-B604AC03A221
P361
description
An instance of the biological ...... shock response in Homo sapiens
@en
name
Regulation of HSF1-mediated heat shock response
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type
label
Regulation of HSF1-mediated heat shock response
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prefLabel
Regulation of HSF1-mediated heat shock response
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P527
P3937
R-HSA-3371453