about
Formation of Senescence-Associated Heterochromatin Foci (SAHF)DSB inducing agents induce double strand DNA breaksTelomere shortening during replicative exhaustionMRN complex binds DNA double strand breaksMRN complex binds shortened telomeresMRN complex bound to DNA ends recruits ATMKAT5 acetylates ATM at DNA DSBsMRN activates ATMMRN complex bound to shortened telomeres recruits ATMKAT5 acetylates ATM at shortened telomeresMRN bound to shortened telomeres activates ATMTP53 binds the CDKN1A promoterEP400 binds CDKN1A promoterTranscriptional activation of CDKN1A by TP53 is inhibited by EP400
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description
An instance of the biological ...... ced Senescence in Homo sapiens
@en
name
DNA Damage/Telomere Stress Induced Senescence
@en
type
label
DNA Damage/Telomere Stress Induced Senescence
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prefLabel
DNA Damage/Telomere Stress Induced Senescence
@en
P2860
P527
P2860
P3937
R-HSA-2559586