about
BMAL1:CLOCK,NPAS2 activates circadian gene expressionRORA activates gene expressionNR1D1 (REV-ERBA) represses gene expressionExpression of BMAL1 (ARNTL).Expression of CLOCKExpression of NPAS2BMAL1 binds CLOCK;NPAS2 forming BMAL1:CLOCK;NPAS2 heterodimerBMAL1:CLOCK;NPAS2 heterodimer is phosphorylated and translocates to the nucleusp-BMAL1:p-CLOCK;NPAS2 binds CRY1 geneExpression of CRYPTOCHROME-1Expression of CRYPTOCHROME-2p-BMAL1:p-CLOCK;NPAS2 binds PER1 geneExpression of PERIOD-1p-BMAL1:p-CLOCK;NPAS2 binds PER2 geneExpression of PERIOD-2p-BMAL1:p-CLOCK;NPAS2 binds NR1D1 geneExpression of NR1D1 (REV-ERBA)p-BMAL1:p-CLOCK;NPAS2 binds RORA geneExpression of RORA (ROR-alpha)CRY proteins stabilize unphosphorylated BMAL1:CLOCK;NPAS2Formation of CRY:PER:Kinase complexCSNK1E;CSNK1D phosphorylate CRY and PER proteinsCRY:PER:Kinase complex translocates to the nucleusCRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimerBeta-TrCP1 binds phosphorylated PER proteinsFBXL3 binds phosphorylated CRY proteinsCRY proteins are ubiquitinylatedBTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteinsExpression of PPARGC1A (PGC-1alpha)RORA; EP300; PPARGC1A; NRIP1 bind ARNTL (BMAL1) geneRORA; EP300 bind NPAS2 geneRORA; EP300; PPARGC1A bind NR1D1 geneNR1D1 (REV-ERBA) binds heme; the ARNTL gene; and recruits corepressors.NR1D1 (REV-ERBA) binds heme; the CLOCK gene; and recruits corepressorsNR1D1 (REV-ERBA) binds heme; the NPAS2 gene; and recruits corepressorsNR1D1 (REV-ERBA) binds heme; the NR1D1 gene; and recruits corepressorsNR1D1 (REV-ERBA) binds heme; the PPARGC1A gene; and recruits corepressors
P361
Q45314193-E7794EFB-D28E-45EE-A5BA-8DB793F9CC4BQ45314195-D14EB3AF-7BC1-4266-8D9D-528CCADB9399Q45314196-3EDC5F7E-5111-4655-8BAA-6F9CA555FF9AQ50287086-A5374E50-790F-40BD-9AD0-538D0DE06EEBQ50287087-9EEE3B5C-591B-4445-9F5A-278F7AEEB6F7Q50287088-74DBDADA-C4F3-4637-8964-29639BC07D8CQ50287089-95E32073-2050-4DB7-8548-7D3A35608812Q50287090-A63FC124-1306-4C1B-AC48-B977F9C43244Q50287091-A3832382-EE15-47B5-B9BF-9589667B777CQ50287092-A8C0E65C-F110-4789-9A23-5869A44B17BAQ50287093-7D1B2CE7-0881-49A5-93F2-C4071F1674EDQ50287094-EA36CBCF-DD26-4592-A629-4A855453622FQ50287095-7CC517D0-83F7-4D88-AADD-E42568A3FC18Q50287096-1A8F5623-E481-46E7-BA17-0B11C8C7F1B4Q50287097-8752B6AD-B6B9-49B2-9C32-3E1A19FE1466Q50287098-6DAC71ED-852C-4308-BAE9-A39F4CCA6343Q50287099-79CD0FC5-332E-4B50-ADF1-0CAD7D2779D6Q50287101-B7886168-21AB-4BB2-A292-097D5D0B8866Q50287102-DA184847-00B7-4619-8139-9ABBC131917EQ50287126-08D11D04-B49C-4B7A-8DEC-B25ED7AECB21Q50287127-213E219F-B158-499B-9CEA-59987E419E5FQ50287128-B0318597-5FB2-4C8E-80A1-E63330E8C163Q50287129-AE95DF16-569D-4AA6-AD87-DD86EC7F33E1Q50287131-6A8BD4D5-FAC2-4232-9EC5-B907D5930DDBQ50287132-5DEF1FD3-F0BD-4427-AD23-19DCC2660FE5Q50287133-7F94164B-BFE4-45ED-A70E-04202C375EE1Q50287134-18C353BA-9171-40A6-AE64-2E824FEFBCD6Q50287135-79CF1ADE-64A9-4BC1-BBB5-FD69698C7AD1Q50287137-9315096B-734E-4AB9-BFD2-DD1498C181DCQ50287138-40E8913A-35E5-4718-87E0-F28724418B10Q50287139-6B1F1CCB-A2AD-4277-9122-5BAFB83D55FDQ50287140-F982B87F-6736-4E98-A7B7-516ED1A576ABQ50287147-A0F7F7BC-41A0-468F-B635-AEBB32076974Q50287148-639BE98F-229C-42AD-B252-04B7F52E479CQ50287149-8B2870FA-843F-4EF5-9C65-E56860EFC7AEQ50287150-C752FABE-639D-4811-BB2B-FA623B1388B1Q50287151-2F7E123D-74A2-4897-8031-5BB11A375097
P361
description
An instance of the biological pathway Circadian Clock in Homo sapiens
@en
name
Circadian Clock
@en
type
label
Circadian Clock
@en
prefLabel
Circadian Clock
@en
P2860
P527
P2860
P3937
R-HSA-400253