about
PARP1;PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP sitePOLB-mediated DNA strand displacement synthesisPARP1;PARP2 dimers bound to FEN1 and POLB autoPARylatePAR-PARP1;PAR-PARP2 dissociate from FEN1 and POLBPARG dePARylates PARP1;PARP2FEN1 bound to POLB cleaves displaced DNA strand (flap)LIG1 binds POLB at long-patch BER siteLIG1 bound to POLB ligates SSBLIG1 and POLB dissociate from repaired dsDNAADPRHL2 hydrolyses poly(ADP-ribose)
P361
Q50287231-360F0356-F8DC-4595-9EA2-7BD809F9D2E1Q50287232-EEE2DE7F-E6A5-40A5-B597-A38144DE5637Q50287233-99FBDCA6-CB54-4E69-9C10-2AD73B42FD5AQ50287234-D437AEC0-FC43-45BA-B032-89BB860546AFQ50287235-FA876D6D-510B-43B1-A571-BCC903C8BE3CQ50287236-36FD599D-8691-4CA5-A747-2C2D3B3E8AC3Q50287238-D05A8141-94B2-423F-A5FA-9FFF06853AA7Q50287239-48E4540D-8AEE-497B-9648-6C4435C9376FQ50287240-00782171-6EDA-4FA8-B894-0F069BE17C76Q50287241-5924133F-7961-4737-9F02-056335C59A11
P361
description
An instance of the biological ...... xcision Repair in Homo sapiens
@en
name
POLB-Dependent Long Patch Base Excision Repair
@en
type
label
POLB-Dependent Long Patch Base Excision Repair
@en
prefLabel
POLB-Dependent Long Patch Base Excision Repair
@en
P2860
P527
P2860
P3937
R-HSA-110362