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FOLR2 binds FOLAFOLR2 transports FOLA from extracellular region to cytosolExtracellular folate import across the plasma membraneCytosolic folate export across the plasma membraneExtracellular 5-methyltetrahydrofolate import across the plasma membraneFolate is reduced to dihydrofolate (DHF)DHF is reduced to tetrahydrofolate (THF)Conversion of cytosolic THF to THF-polyglutamateConversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamateCytosolic tetrahydrofolate import across the inner mitochondrial membraneMitochondrial tetrahydrofolate export across the inner mitochondrial membraneConversion of mitochondrial THF to THF-polyglutamateSHMT2 tetramer transfers CH2OH group from 5;10MTHF to glycineMTHFD1L ligates HCOOH to THF to form 10-formyl-THFTHF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate10-formylTHF polyglutamate <=> 5;10-methenylTHF polyglutamate + H2O5;10-methenylTHF polyglutamate + NADPH + H+ <=> 5;10-methyleneTHF polyglutamate + NADP+Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5;10-methyleneTHF polyglutamate + glycine5;10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+5;10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine5;10-methyleneTHF polyglutamate + NADP+ <=> 5;10-methenylTHF polyglutamate + NADPH + H+5;10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamateALDH1L1 dehydrogenates 10-formyl-THFPG to THFPGMTHFD2; D2L oxidise 5;10-methylene-THF to 5;10-methenyl-THFMTHFD2; D2L oxidise 5;10-methenyl-THF to 10-formyl-THFALDH1L2 dehydrogenates 10-formyl-THFPG to THFPGMTHFD1L transforms 10-formyl-THF to HCOOH and THFHCOOH translocated from mitochondrial matrix to cytosolMTHFS transforms 5-formyl-THFPG to 5;10-methenyl-THFPG
P361
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P361
description
An instance of the biological pathway Metabolism of folate and pterines in Homo sapiens
@en
name
Metabolism of folate and pterines
@en
type
label
Metabolism of folate and pterines
@en
prefLabel
Metabolism of folate and pterines
@en
P527
P2860
P3937
R-HSA-196757