about
C-peptideproinsulinInsulinOxidation of cysteine to cystine in ProinsulinCystine-bonded Proinsulin translocates from the endoplasmic reticulum to the GolgiZnT6 transports zinc into the golgi apparatusZnT7 transports zinc into the golgi apparatusProinsulin binds zinc and calcium forming Proinsulin:zinc:calciumProinsulin:Zinc:Calcium complex translocates to immature secretory granuleProcessing of Proinsulin to InsulinZnT5 transports zinc into secretory granules in pancreatic beta cellsSLC30A8 transports Zn2+ from cytosol to secretory granuleInsulin secretory granule translocates to cell cortexInsulin secretory granules translocate across the cortical actin network to dock at plasma membraneExocyst complex formationinsulin A chainPCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))Insulin secretory granule translocates across the cortical actin networkInsulin secretory granule docks at the plasma membraneinsulin B chain
P361
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P361
description
An instance of the biological pathway Insulin processing in Homo sapiens
@en
name
Insulin processing
@en
type
label
Insulin processing
@en
prefLabel
Insulin processing
@en
P2860
P527
P2860
P3937
R-HSA-264876