about
Cargo recognition for clathrin-mediated endocytosisInitial binding of AP-2 and clathrin to PI(4;5)P2FCHo proteins bind nascent clathrin-coated pitRecruitment of AP-2 complex and clathrinPIP5K1C phosphorylates PI(4)P to PI(4;5)P2AAK1 phosphorylates AP-2 mu subunit at T156CLASP proteins and cargo are recruited to the nascent clathrin-coated pitClathrin recruits PIK3C2AClathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3;4)P2F- and N- BAR domain proteins bind the clathrin-coated pitSNX9 recruits components of the actin polymerizing machineryBAR domain proteins recruit dynaminEndophilins recruit synaptojanins to the clathrin-coated pitSYNJ hydrolyze PI(4;5)P2 to PI(4)PDynamin-mediated GTP hydrolysis promotes vesicle scissionClathrin recruits auxilins to the clathrin-coated vesicleAuxilin recruits HSPA8:ATP to the clathrin-coated vesicleHSPA8-mediated ATP hydrolysis promotes vesicle uncoatingRAB5 and GAPVD1 bind AP-2Dissociation of AAK1 and dephosphorylation of AP-2 mu2Dissociation of clathrin-associated proteins
P361
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P361
description
An instance of the biological pathway Clathrin-mediated endocytosis in Homo sapiens
@en
name
Clathrin-mediated endocytosis
@en
type
label
Clathrin-mediated endocytosis
@en
prefLabel
Clathrin-mediated endocytosis
@en
P2860
P527
P2860
P3937
R-HSA-8856828