Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.

Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.

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http://www.wikidata.org/entity/Q45323294
Advantages and Challenges of Dried Blood Spot Analysis by Mass Spectrometry Across the Total Testing ProcessComprehensive analysis of protein digestion using six trypsins reveals the origin of trypsin as a significant source of variability in proteomics.Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: applications to bioanalysis in toxicity studies with antibody-drug conjugates.Multiplexed quantitation of endogenous proteins in dried blood spots by multiple reaction monitoring-mass spectrometryDried blood spot proteomics: surface extraction of endogenous proteins coupled with automated sample preparation and mass spectrometry analysis.State-of-the-art dried blood spot analysis: an overview of recent advances and future trends.The use of mass spectrometry to analyze dried blood spots.Challenges and opportunities in mass spectrometric analysis of proteins from dried blood spots.Clinical perspectives of dried blood spot protein quantification using mass spectrometry methods.What is next for dried blood spots?Automated DBS microsampling, microscale automation and microflow LC-MS for therapeutic protein PK.Thermal inactivation of enzymes and pathogens in biosamples for MS analysis.A dried blood spot update: still an important bioanalytical technique?Evaluation of dried blood spots for the quantification of therapeutic monoclonal antibodies and detection of anti-drug antibodies.Instant on-paper protein digestion during blood spot sampling.Expanding the knowledge on dried blood spots and LC-MS-based protein analysis: two different sampling materials and six protein targets.Evaluation of peripheral blood microsampling techniques in combination with liquid chromatography-high resolution mass spectrometry for the determination of drug pharmacokinetics in clinical studies.
P2860

Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.

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http://www.wikidata.org/entity/Q45323294
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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2012年學術文章
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name
Quantitation of therapeutic pr ...... cal methods in drug discovery.
@en
Quantitation of therapeutic pr ...... cal methods in drug discovery.
@nl
type
label
Quantitation of therapeutic pr ...... cal methods in drug discovery.
@en
Quantitation of therapeutic pr ...... cal methods in drug discovery.
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prefLabel
Quantitation of therapeutic pr ...... cal methods in drug discovery.
@en
Quantitation of therapeutic pr ...... cal methods in drug discovery.
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P1433
P1476
P2093
P2860
P304
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P433
P478
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P698
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P1433
P1476
Quantitation of therapeutic pr ...... cal methods in drug discovery.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698