about
A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazolineRapid generation of privileged substructure-based compound libraries with structural diversity and drug-likeness.Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities.Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation.Most efficient routes for the synthesis of alpha,beta-diamino acid-derived compounds.Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating.Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors.Gold(I)-catalyzed cascade approach for the synthesis of tryptamine-based polycyclic privileged scaffolds as α1-adrenergic receptor antagonists.Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties( R )-3-Amino-1-((3a S ,7a S )-octahydro-1 H -indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modelingAsymmetric Michael Addition of N-tert-Butanesulfinyl Imidate with α,β-Unsaturated Diesters: Scope and Application to the Synthesis of Indanone DerivativesDesign, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptorDiscovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinaseApplication of Nickel(II) Complexes to the Efficient Synthesis of α- or β-Amino AcidsSynthesis of 2-Phenylnaphthalenes through Gold-Catalyzed Dimerization via a Highly Selective Carbon Nucleophile PathwaySynthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade ReactionsRegioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinonesSilver- and Gold-Mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium HexafluorostilbatesSignal Transduction, Ageing and DiseaseAdenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD miceMethods to Quantify the NF-κB Pathway During Senescence
P50
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P50
description
researcher ORCID: 0000-0001-7409-6090
@en
name
Lei Zhang
@ast
Lei Zhang
@en
Lei Zhang
@es
Lei Zhang
@nl
Lei Zhang
@sl
type
label
Lei Zhang
@ast
Lei Zhang
@en
Lei Zhang
@es
Lei Zhang
@nl
Lei Zhang
@sl
prefLabel
Lei Zhang
@ast
Lei Zhang
@en
Lei Zhang
@es
Lei Zhang
@nl
Lei Zhang
@sl
P1053
P-3012-2017
P106
P21
P31
P3829
P496
0000-0001-7409-6090
P569
2000-01-01T00:00:00Z