Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation. - Wikidata - awgldk - TriplyDB

Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation.

Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation.

http://www.wikidata.org/entity/Q45342642

about

The role of inflammasome in Alzheimer's disease NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease.Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1.Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome.Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway.Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit.Negative regulation of the inflammasome: keeping inflammation under control.The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine.Inflammasome activation and innate immunity in Alzheimer's disease.Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2 Inhibitory effect of ethanol extract of Nannochloropsis oceanica on lipopolysaccharide-induced neuroinflammation, oxidative stress, amyloidogenesis and memory impairment.Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease.Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's disease.The Potential Therapeutic Effects of Artesunate on Stroke and Other Central Nervous System Diseases.Paeoniflorin Atttenuates Amyloidogenesis and the Inflammatory Responses in a Transgenic Mouse Model of Alzheimer's Disease.Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice.Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation.

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P2860

Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation.

http://www.wikidata.org/entity/Q45342642

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2013 nî lūn-bûn

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2013年學術文章

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2013年學術文章

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Antimalarial drug artemisinin ...... NLRP3 inflammasome activation.

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Antimalarial drug artemisinin ...... NLRP3 inflammasome activation.

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Antimalarial drug artemisinin ...... NLRP3 inflammasome activation.

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Chu-Chu Zhang

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Hai-Qiang Zou

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Jian-Quan Shi

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Jiang-Bo Wang

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Jun Xu

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Xin-Xin Cheng

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Xiu-Lan Sun

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Ying-Dong Zhang

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P2860

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes.

The antimalarial drug artemisinin alkylates heme in infected mice.

Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells.

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