Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry.
about
Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1.Structure modeling of all identified G protein-coupled receptors in the human genomeMolecular dynamics simulations on SDF-1alpha: binding with CXCR4 receptorIdentification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 bindingIdentification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.Chemokine receptors: emerging opportunities for new anti-HIV therapies.Chemokine receptor internalization and intracellular trafficking.Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2.Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues.Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.Evidence for common structural determinants of human immunodeficiency virus type 1 coreceptor activity provided through functional analysis of CCR5/CXCR4 chimeric coreceptorsComparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies.Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responses.
P2860
Q24794092-E87B830A-2178-4ED5-8798-1D7A291A7875Q25256886-C3827E54-9EB8-4116-9594-127FF190C395Q30332403-891ABD5A-A6B2-4612-B09C-7650E6D6AD3BQ34349528-76867F4D-929D-4945-B5EE-68F450CDDAC0Q34465007-751F3389-697B-4B42-B39E-03174631F9AEQ35050395-CCF8C22D-1272-413D-A874-D80360726889Q36184275-A3C4F7BA-460D-4DAE-A43A-3EAB076FDBB9Q36334083-23D944EB-4F31-4706-A60C-C6DCA1B9302CQ36674792-89DAFD2E-B601-4604-91A7-7B9D622B9AA7Q37479274-3F8981EC-B72A-40C6-B1E4-6687645F2E57Q37596456-7BFEDAF4-675F-4779-A6A6-F44E4CB84F48Q37599363-5E32DA2F-F486-4B19-8454-90461AEE16EAQ37834097-AEE6A8FE-B1FE-4F18-B39A-E98244DBDC0AQ39605336-CB86769F-44E0-4B16-AB12-6F0D0FDCD3B8Q40007908-193B9A71-EC68-4D85-BBDD-DDD86A67C445Q40132975-62320E77-CF5F-42D9-A8CA-AAC4EE2E7960Q40781201-7602073D-4D54-488C-BC65-2A83568807A3Q42817463-CBB0D618-EF16-4A14-9213-F3BD6F2C4C15
P2860
Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Substitutions in a homologous ...... mbrane fusion and virus entry.
@en
Substitutions in a homologous ...... mbrane fusion and virus entry.
@nl
type
label
Substitutions in a homologous ...... mbrane fusion and virus entry.
@en
Substitutions in a homologous ...... mbrane fusion and virus entry.
@nl
prefLabel
Substitutions in a homologous ...... mbrane fusion and virus entry.
@en
Substitutions in a homologous ...... mbrane fusion and virus entry.
@nl
P2860
P356
P1476
Substitutions in a homologous ...... mbrane fusion and virus entry.
@en
P2093
P2860
P304
23774-23782
P356
10.1074/JBC.M003438200
P407
P577
2000-08-01T00:00:00Z