Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
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Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistanceGenotypic characterization of the DNA polymerase and sensitivity to antiviral compounds of foscarnet-resistant herpes simplex virus type 1 (HSV-1) derived from a foscarnet-sensitive HSV-1 strain.Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementGenotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo.Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity.Testing the susceptibility of human herpesviruses to antivirals.Management of multidrug-resistant viruses in the immunocompromised host.Antiviral drug resistance in herpesviruses other than cytomegalovirus.Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease.Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.Bone marrow transplantation in a child with Wiskott-Aldrich syndrome latently infected with acyclovir-resistant (ACV(r)) herpes simplex virus type 1: emergence of foscarnet-resistant virus originating from the ACV(r) virus.Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues.Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases.Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis studyMultiple herpes simplex virus infections with various resistance patterns in a matched unrelated donor transplant recipient.Importance of C-terminus of herpes simplex virus type 1 thymidine kinase for maintaining thymidine kinase and acyclovir-phosphorylation activities.Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy.Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1.Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients
P2860
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P2860
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Characterization of the DNA po ...... t therapy sequentially failed.
@en
Characterization of the DNA po ...... t therapy sequentially failed.
@nl
type
label
Characterization of the DNA po ...... t therapy sequentially failed.
@en
Characterization of the DNA po ...... t therapy sequentially failed.
@nl
prefLabel
Characterization of the DNA po ...... t therapy sequentially failed.
@en
Characterization of the DNA po ...... t therapy sequentially failed.
@nl
P356
P1476
Characterization of the DNA po ...... t therapy sequentially failed.
@en
P2093
P304
P356
10.1086/314900
P407
P577
1999-08-01T00:00:00Z