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Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysLeucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's diseaseThe role of the LRRK2 gene in ParkinsonismLRRK2 at the interface of autophagosomes, endosomes and lysosomesBioUSeR: a semantic-based tool for retrieving Life Science web resources driven by text-rich user requirementsThe LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeletonThe WD40 domain is required for LRRK2 neurotoxicity.Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.Role of LRRK2 kinase dysfunction in Parkinson diseaseExpression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.Origin and Diversification of Meprin Proteases.Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.LRRK2 mutations and neurotoxicant susceptibilityLeucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.Update on the functional biology of Lrrk2.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate.LRRK2: cause, risk, and mechanism.Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?Interaction of LRRK2 with kinase and GTPase signaling cascadesLRRK2 and Autophagy.Characterization of the Roco protein family in Dictyostelium discoideum.The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.Structural and functional in silico analysis of LRRK2 missense substitutions.LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Ancient origin of the Parkinson disease gene LRRK2.
@en
Ancient origin of the Parkinson disease gene LRRK2.
@nl
type
label
Ancient origin of the Parkinson disease gene LRRK2.
@en
Ancient origin of the Parkinson disease gene LRRK2.
@nl
prefLabel
Ancient origin of the Parkinson disease gene LRRK2.
@en
Ancient origin of the Parkinson disease gene LRRK2.
@nl
P1476
Ancient origin of the Parkinson disease gene LRRK2.
@en
P2888
P356
10.1007/S00239-008-9122-4
P4011
a3f0313b004586e4535a1d76064cb9d5b73e8c1c
P407
P50
P577
2008-06-04T00:00:00Z
P5875
P6179
1035283815