about
B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB.T-oligo as an anticancer agent in colorectal cancerRPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain.Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor ActivityDiscovery of new G-quadruplex binding chemotypes.Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products.G-Quadruplex binding enantiomers show chiral selective interactions with human telomere.Oxoisoaporphine as Potent Telomerase Inhibitor.Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS.Loop flexibility in human telomeric quadruplex small-molecule complexes.Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo.Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming.Differential nuclear ATRX expression in sarcomas.Exploring the mechanism of inhibition of human telomerase by cysteine-reactive compounds.Molecular Recognition of Parallel DNA Quadruplex d(TTAGGGT)4 by Mitoxantrone: Binding with 1:2 Stoichiometry Leading to Thermal Stabilization and Telomerase Inhibition.Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitroDiscovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Telomere maintenance as a target for drug discovery.
@en
Telomere maintenance as a target for drug discovery.
@nl
type
label
Telomere maintenance as a target for drug discovery.
@en
Telomere maintenance as a target for drug discovery.
@nl
prefLabel
Telomere maintenance as a target for drug discovery.
@en
Telomere maintenance as a target for drug discovery.
@nl
P2093
P356
P1476
Telomere maintenance as a target for drug discovery.
@en
P2093
Joana Soares
Michael B Jarstfer
Vijay Sekaran
P304
P356
10.1021/JM400528T
P407
P577
2013-10-15T00:00:00Z