A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.
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Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopesSix amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody.The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfacesStructure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene.
P2860
A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.
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2010 nî lūn-bûn
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2010年の論文
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name
A human FVIII inhibitor modula ...... site distant from its epitope.
@en
A human FVIII inhibitor modula ...... site distant from its epitope.
@nl
type
label
A human FVIII inhibitor modula ...... site distant from its epitope.
@en
A human FVIII inhibitor modula ...... site distant from its epitope.
@nl
prefLabel
A human FVIII inhibitor modula ...... site distant from its epitope.
@en
A human FVIII inhibitor modula ...... site distant from its epitope.
@nl
P2093
P50
P1476
A human FVIII inhibitor modula ...... site distant from its epitope
@en
P2093
B P Atanasov
C Planchais
D Saboulard
J-L Plantier
J-M Saint-Remy
M Jacquemin
P304
P356
10.1111/J.1538-7836.2010.03878.X
P577
2010-03-30T00:00:00Z