Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.
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Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological CalciumDaboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant ActivityDimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B.The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex.The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor.Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study.The regulation of factor IXa by supersulfated low molecular weight heparin.Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cellsExosites in the substrate specificity of blood coagulation reactions.The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.The N-terminal epidermal growth factor-like domain of coagulation factor IX. Probing its functions in the activation of factor IX and factor X with a monoclonal antibody.Residues 88-109 of factor IXa are important for assembly of the factor X activating complex.Surface-loop residue Lys316 in blood coagulation Factor IX is a major determinant for Factor X but not antithrombin recognition.Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1.Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.Definition of a factor Va binding site in factor Xa.Contribution of magnesium in binding of factor IXa to the phospholipid surface: implications for vitamin K-dependent coagulation proteins.Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants.Hypersulfated low molecular weight heparin with reduced affinity for antithrombin acts as an anticoagulant by inhibiting intrinsic tenase and prothrombinase.Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property.Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa.Defining the factor Xa-binding site on factor Va by site-directed glycosylation.Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein.Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes.Contribution of basic residues of the autolysis loop to the substrate and inhibitor specificity of factor IXa.Functional analysis of the EGF-like domain mutations Pro55Ser and Pro55Leu, which cause mild hemophilia B.
P2860
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P2860
Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
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1999年學術文章
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1999年學術文章
@zh-hant
name
Protease and EGF1 domains of f ...... interaction with factor VIIIa.
@en
Protease and EGF1 domains of f ...... VIIIa. Importance of helix 330
@nl
type
label
Protease and EGF1 domains of f ...... interaction with factor VIIIa.
@en
Protease and EGF1 domains of f ...... VIIIa. Importance of helix 330
@nl
prefLabel
Protease and EGF1 domains of f ...... interaction with factor VIIIa.
@en
Protease and EGF1 domains of f ...... VIIIa. Importance of helix 330
@nl
P2860
P356
P1476
Protease and EGF1 domains of f ...... interaction with factor VIIIa.
@en
P2093
P2860
P304
18477-18486
P356
10.1074/JBC.274.26.18477
P407
P577
1999-06-01T00:00:00Z